Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.30 extracted from

  • Murthy, S.; Desantis, J.; Verheugd, P.; Maksimainen, M.M.; Venkannagari, H.; Massari, S.; Ashok, Y.; Obaji, E.; Nkizinkinko, Y.; Luescher, B.; Tabarrini, O.; Lehtioe, L.
    4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10 (2018), Eur. J. Med. Chem., 156, 93-102 .
    View publication on PubMed
Search for more literature for 2.4.2.30

Inhibitors

Inhibitors Comment Organism Structure
4,4'-(methylmino)dibenzamide 26% inhibition at 0.01 mM Homo sapiens
4,4'-thiodibenzamide 30% inhibition at 0.01 mM Homo sapiens
4-(2-fluorophenoxy)benzamide
-
 Homo sapiens
4-(2-phenoxyethoxy)benzamide
-
 Homo sapiens
4-(4-aminophenoxy)benzamide
-
 Homo sapiens
4-(4-carbamoylphenoxy)benzoic acid
-
 Homo sapiens
4-(4-formylphenoxy)benzamide
-
 Homo sapiens
4-(4-hydroxyphenoxy)benzamide
-
 Homo sapiens
4-(4-methoxyphenoxy)benzamide
-
 Homo sapiens
4-(4-nitrobenzoyl)benzamide 24% inhibition at 0.01 mM Homo sapiens
4-(benzyloxy)benzamide
-
 Homo sapiens
4-(pyridin-2-yloxy)benzamide 49% inhibition at 0.01 mM Homo sapiens
4-butoxybenzamide
-
 Homo sapiens
4-carbamoylphenyl benzoate
-
 Homo sapiens
4-ethoxybenzamide
-
 Homo sapiens
4-hydroxybenzamide 27% inhibition at 0.01 mM Homo sapiens
4-methoxybenzamide
-
 Homo sapiens
4-phenoxybenzamide
-
 Homo sapiens
4-[(2-bromophenyl)methoxy]benzamide
-
 Homo sapiens
4-[(2-fluorophenyl)methoxy]benzamide
-
 Homo sapiens
4-[(3,5-dimethylphenyl)methoxy]benzamide
-
 Homo sapiens
4-[(3-bromophenyl)methoxy]benzamide
-
 Homo sapiens
4-[(3-fluorophenyl)methoxy]benzamide
-
 Homo sapiens
4-[(4-cyanophenyl)thio]benzamide 16% inhibition at 0.01 mM Homo sapiens
4-[(4-fluorophenyl)methoxy]benzamide
-
 Homo sapiens
4-[(4-methylphenyl)methoxy]benzamide
-
 Homo sapiens
4-[(naphthalen-1-yl)methoxy]benzamide
-
 Homo sapiens
4-[(propan-2-yl)oxy]benzamide
-
 Homo sapiens
4-[(pyridin-2-yl)methoxy]benzamide
-
 Homo sapiens
4-[1-[4-(propan-2-yl)phenyl]ethoxy]benzamide 16% inhibition at 0.01 mM Homo sapiens
4-[4-(1-aminoethenyl)phenoxy]benzamide
-
 Homo sapiens
4-[[4-(aminocarbonyl)benzyl]oxy]benzamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q53GL7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
ARTD10
-
 Homo sapiens
diphtheria toxin-like ADP-ribosyltranferase
-
 Homo sapiens
mono-ADP-ribosyltransferase
-
 Homo sapiens
PARP10
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00018
-
 pH and temperature not specified in the publication Homo sapiens 4-(4-carbamoylphenoxy)benzoic acid
0.00023
-
 pH and temperature not specified in the publication Homo sapiens 4-[(2-fluorophenyl)methoxy]benzamide
0.00033
-
 pH and temperature not specified in the publication Homo sapiens 4-[4-(1-aminoethenyl)phenoxy]benzamide
0.00071
-
 pH and temperature not specified in the publication Homo sapiens 4-(4-formylphenoxy)benzamide
0.00072
-
 pH and temperature not specified in the publication Homo sapiens 4-butoxybenzamide
0.0011
-
 pH and temperature not specified in the publication Homo sapiens 4-phenoxybenzamide
0.0013
-
 pH and temperature not specified in the publication Homo sapiens 4-(4-aminophenoxy)benzamide
0.0013
-
 pH and temperature not specified in the publication Homo sapiens 4-[(propan-2-yl)oxy]benzamide
0.00135
-
 pH and temperature not specified in the publication Homo sapiens 4-[(pyridin-2-yl)methoxy]benzamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens 4-(4-methoxyphenoxy)benzamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens 4-(benzyloxy)benzamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens 4-[(naphthalen-1-yl)methoxy]benzamide
0.0017
-
 pH and temperature not specified in the publication Homo sapiens 4-(2-fluorophenoxy)benzamide
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 4-(4-hydroxyphenoxy)benzamide
0.0019
-
 pH and temperature not specified in the publication Homo sapiens 4-(2-phenoxyethoxy)benzamide
0.002
-
 pH and temperature not specified in the publication Homo sapiens 4-[[4-(aminocarbonyl)benzyl]oxy]benzamide
0.0022
-
 pH and temperature not specified in the publication Homo sapiens 4-[(3-bromophenyl)methoxy]benzamide
0.0028
-
 pH and temperature not specified in the publication Homo sapiens 4-methoxybenzamide
0.0033
-
 pH and temperature not specified in the publication Homo sapiens 4-[(3-fluorophenyl)methoxy]benzamide
0.0035
-
 pH and temperature not specified in the publication Homo sapiens 4-ethoxybenzamide
0.0038
-
 pH and temperature not specified in the publication Homo sapiens 4-[(2-bromophenyl)methoxy]benzamide
0.0045
-
 pH and temperature not specified in the publication Homo sapiens 4-[(3,5-dimethylphenyl)methoxy]benzamide
0.0073
-
 pH and temperature not specified in the publication Homo sapiens 4-carbamoylphenyl benzoate
0.0079
-
 pH and temperature not specified in the publication Homo sapiens 4-[(4-fluorophenyl)methoxy]benzamide
0.0093
-
 pH and temperature not specified in the publication Homo sapiens 4-[(4-methylphenyl)methoxy]benzamide